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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
10/02/2017 |
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Data da última atualização: |
05/09/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GOMIDE, M.; LEMOS, F.; REIS, D. R. de L.; JOSÉ, G.; LOPES, M.; MACHADO, M. A.; ALVES, T.; COELHO, C. M. |
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Afiliação: |
Mayna Gomide, UFJF; Fernanda Lemos, UFMG; DANIELE RIBEIRO DE LIMA REIS FAZA, CNPGL; Gustavo José, UnB; Miriam Lopes, UFMG; MARCO ANTONIO MACHADO, CNPGL; Tânia Alves, Fundação Oswaldo Cruz; Cíntia Marques Coelho, UFJF; UnB. |
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Título: |
Identification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Revista Brasileira de Farmacognosia, v. 26, n. 5, p. 627-633, 2016. |
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DOI: |
http://dx.doi.org/10.1016/j.bjp.2016.04.003 |
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Idioma: |
Inglês |
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Conteúdo: |
In spite of advances in colorectal cancer treatments, approximately 1.4 million new global cases are estimated for 2015. In this sense, Brazilian plant diversity offers a multiplicity of essential oils as prospective novel anticancer compounds. This study aimed to evaluate the antiproliferative effect of the essential oils from four Lippia species in CT26.WT colon tumor cells, as a measurement of cell cycle phase distribution and microRNA expression. CT26.WT showed cell cycle arrest at G2/M phase after treatment with 100 g/ml of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Lippia sidoides Cham., and Lippia lacunosa Mart. & Schauer, Verbenaceae, essential oils and, at the same concentration, Lippia rotundifolia Cham. essential oil caused an augment of G0/G1 phase. The miRNA expression profiling shows change of expression in key oncogenic miRNAs genes after treatment. Our findings suggest growth inhibition mechanisms for all four essential oils on CT26.WT cells involving direct or indirect interference on cell cycle arrest and/or oncogenic miRNAs expression. |
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Palavras-Chave: |
Cell cycle phases; Colorectal cancer; CT26WT; Lippia essential oil. |
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Thesaurus Nal: |
microRNA. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/155311/1/Cnpgl-2016-BrazJPharmac-Identification.pdf
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Marc: |
LEADER 02014naa a2200277 a 4500
001 2063533
005 2022-09-05
008 2016 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1016/j.bjp.2016.04.003$2DOI
100 1 $aGOMIDE, M.
245 $aIdentification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line.$h[electronic resource]
260 $c2016
520 $aIn spite of advances in colorectal cancer treatments, approximately 1.4 million new global cases are estimated for 2015. In this sense, Brazilian plant diversity offers a multiplicity of essential oils as prospective novel anticancer compounds. This study aimed to evaluate the antiproliferative effect of the essential oils from four Lippia species in CT26.WT colon tumor cells, as a measurement of cell cycle phase distribution and microRNA expression. CT26.WT showed cell cycle arrest at G2/M phase after treatment with 100 g/ml of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Lippia sidoides Cham., and Lippia lacunosa Mart. & Schauer, Verbenaceae, essential oils and, at the same concentration, Lippia rotundifolia Cham. essential oil caused an augment of G0/G1 phase. The miRNA expression profiling shows change of expression in key oncogenic miRNAs genes after treatment. Our findings suggest growth inhibition mechanisms for all four essential oils on CT26.WT cells involving direct or indirect interference on cell cycle arrest and/or oncogenic miRNAs expression.
650 $amicroRNA
653 $aCell cycle phases
653 $aColorectal cancer
653 $aCT26WT
653 $aLippia essential oil
700 1 $aLEMOS, F.
700 1 $aREIS, D. R. de L.
700 1 $aJOSÉ, G.
700 1 $aLOPES, M.
700 1 $aMACHADO, M. A.
700 1 $aALVES, T.
700 1 $aCOELHO, C. M.
773 $tRevista Brasileira de Farmacognosia$gv. 26, n. 5, p. 627-633, 2016.
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Embrapa Gado de Leite (CNPGL) |
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